循環器の病気

小坂利幸(循環器内科)

略歴

1980年

東北大学医学部卒業

1980-1984年

静岡済生会総合病院

1984-1987年

名古屋大学大学院医学研究科
(名古屋大学環境医学研究所、
専攻:心臓電気生理学、医学博士)

1987-1988年

名古屋大学環境医学研究所 助手

1988-1992年

米国エモリー大学医学部留学

1992-2010年

静岡済生会総合病院
循環器内科医長、不整脈科部長、
名古屋大学臨床准教授を歴任

資格

日本循環器学会認定循環器専門医
日本不整脈心電学会認定不整脈専門医
日本内科学会認定内科医

所属学会

日本循環器学会
日本不整脈心電学会
日本内科学会

原著論文

Osaka T, Kodama I, Tsuboi N, Toyama J, Yamada K. Effects of activation sequence and anisotropic cellular geometry on the repolarization phase of action potential of dog ventricular muscles. Circulation 1987;76:226-236

Osaka T, Kodama I, Toyama J, Yamada K. Effects of bepridil on ventricular depolarization and repolarization of rabbit isolated hearts with particular reference to its possible proarrhythmic properties. Br J Pharmacol 1988;93:775-780

Osaka T, Ramza BM, Tan RC, Joyner RW. Developmental changes in the electrophysiologic properties of rabbit papillary muscles. Pediatr Res 1989;26:543-547

Ramza BM, Tan RC, Osaka T, Joyner RW. Cellular mechanism of the functional refractory period in ventricular muscle. Circ Res 1990;66:147-162

Joyner RW, Ramza BM, Osaka T, Tan RC. Cellular mechanisms of delayed recovery of excitability in ventricular tissue. Am J Physiol. 1991;260:H225-233

Osaka T, Joyner RW. Developmental changes in calcium currents of rabbit ventricular cells. Circ Res 1991;68:788-796

Tan RC, Osaka T, Joyner RW. Experimental model of effects on normal tissue of injury current from ischemic region. Circ Res 1991;69:965-974

Osaka T, Joyner RW. Developmental changes in the beta-adrenergic modulation of calcium currents in rabbit ventricular cells. Circ Res. 1992;70:104-115

Osaka T, Joyner RW, Kumar R. Postnatal decrease in muscarinic cholinergic influence on Ca2+ currents of rabbit ventricular cells. Am J Physiol. 1993;264:H1916-H1925

Osaka T, Itoh A, Kodama I. Action potential remodeling in the human right atrium with chronic lone atrial fibrillation. Pacing Clin Electrophysiol 2000;23:960-965

Osaka T, Yamazaki M, Yokoyama E, Ito A, Kodama I. Sotalol reverses remodeled action potential in patients with chronic atrial fibrillation but does not prevent arrhythmia recurrence. J Cardiovasc Electrophysiol 2004;15:877-884.

Harada M, Osaka T, Yokoyama E, Takemoto Y, Ito A, Kodama I. Biventricular pacing has an advantage over left ventricular epicardial pacing alone to minimize proarrhythmic perturbation of repolarization. J Cardiovasc Electrophysiol 2006;17:151-156

Yamazaki M, Osaka T, Yokoyama E, Kodama I. A case of short-coupled variant of torsade de pointes characterized by spatial heterogeneity of action potential duration and its restitution kinetics. J Interv Card Electrophysiol. 2006;17:35-340

Yokoyama E, Osaka T, Takemoto Y, Suzuki T, Ito A, Kamiya K, Kodama I. Paroxysmal atrial fibrillation maintained by nonpulmonary vein sources can be predicted by dominant frequency analysis of atriopulmonary electrograms. J Cardiovasc Electrophysiol 2009;20:630-636

Harada M, Osaka T, Yokoyama E, Takemoto Y, Ito A, Kodama I. Action potential characteristics in the sinus venosa of patients with and without atrial flutter. Circ J 2009;73:647-653

Osaka T, Yokoyama E, Kushiyama Y, Hasebe H, Kuroda Y, Suzuki T, Kodama I. Opposing effects of bepridil on ventricular repolarization in humans. Inhomogeneous prolongation of the action potential duration vs flattening of its restitution kinetics. Circ J 2009;73:1612-1618

Takemoto Y, Hasebe H, Osaka T, Yokoyama E, Kushiyama Y, Suzuki T, Kuroda Y, Ichikawa C, Kamiya K, Kodama I. Right ventricular septal pacing preserves long-term left ventricular function via minimizing pacing-induced left ventricular dyssynchrony in patients with normal baseline QRS duration. Circ J 2009;73:1829-1835

Kushiyama Y, Osaka T, Yokoyama E, Hasebe H, Kuroda Y, Kamiya K, Kodama I. Verapamil eliminates the hierarchical nature of activation frequencies from the pulmonary veins to the atria during paroxysmal atrial fibrillation. Heart Rhythm. 2010;7:577-583

Osaka T, Yokoyama E, Hasebe H, Kodama I. Effects of Chronic Amiodarone on the Electrical Restitution in the Human Ventricle With Reference to Its Antiarrhythmic Efficacy. J Cardiovasc Electrophysiol 2011;22:669-676

Suzuki T, Osaka T, Kuroda Y, Hasebe H, Yokoyama E, Kamiya K, Kodama I. Potential benefit of Bachmann's bundle pacing on left ventricular performance in patients with cardiac resynchronized therapy. Circ J. 2012;76:2799-806.

刊行物

小坂利幸、児玉逸雄:抗不整脈薬による催不整脈作用. 循環器NOW 15 循環器疾患の薬物療法(横山光宏 編集), p226-p229, 南江堂, 東京, 1997

小坂利幸、児玉逸雄:難治性心房細動対策. 治療学 2000, 34, 55-59

小坂利幸:クラスIII薬のめざすところ-不整脈の抑止と予後の改善. 循環器病への挑戦XX不整脈治療の最前線, p13-p20, ライフメディコム, 名古屋, 2001

小坂利幸:心室細動の発生機序に関する最近の話題. Therapeutic Research 2005, 26, 5-12

小坂利幸:抗不整脈薬の新たな標的-APD回復特性.  Medical Topics Series 不整脈2005 (井上博 編集),  p34-p47, メディカルビュー社, 東京, 2005

小坂利幸、竹本芳雄:心室ペーシング部位の左室機能への影響-右室心尖部ペーシングと右室中隔ペーシングの比較. 心室中隔ペーシングの実際(安部治彦 編集), p84-p92, メディカルレビュー社, 東京 2007

小坂利幸、児玉逸雄:突然死予防のためのアミオダロンの有用性と限界. Cardiac Practice 2008, 19, 69-75